Diabetes Medication May Decrease BMI in Obese Teens

The obesity rate among children has tripled since 1960, with 32% of US children considered overweight or obese, and many of them suffering the same weight-related problems as adults: diabetes mellitus type 2, hypertension and cardiovascular disease.  In the February issue of Archives of Pediatrics & Adolescent Medicine, a report by Darrell M. Wilson, M.D., of Stanford University and the Lucile S. Packard Children’s Hospital, Stanford, Calif., along with colleagues in the Glaser Pediatric Research Network Obesity Study Group showed that teens given Metformin, a common pill given to type 2 diabetics, helped lower their BMI score. BMI is an indicator of body fat percentage—the lower your BMI the less risk you have for cardiovascular disease and other weight-related disorders.

The research group split 77 obese teenagers, ages 13 to 18, into two groups. Both groups were put on a “lifestyle intervention program” which included dietary changes and increased physical activity. One group received 2,000 mg of Metformin XR per day and the other group received a placebo. After 38 weeks, the kids receiving the Metformin XR showed a significantly lowered BMI than the teens receiving the placebo, even though all the teens were on the same diet and exercise plan. Unfortunately, once the drug was discontinued, the BMI in the teens previously taking Metformin again went up. This certainly lends credence to my long-held belief that Metformin can be an effective weight-management tool for some people.

In addition to helping with weight problems, Metformin works very similarly to Resveratrol and has significant anti-aging properties. Like Resveratrol, it helps regulate the Sirt-2 gene, helping protect DNA from damage, so it’s a very important product.

I think Metformin can be a helpful treatment for kids who are overweight. It will improve insulin resistance which will assist with weight loss, which is a great thing! Many of these overweight young kids have developed insulin resistance, so many of them do need this extra boost. Metformin can actually help some overweight teens avoid the development of type 2 diabetes, when used in conjunction with diet and exercise.

It’s not a magic pill, and you still need diet and exercise to get the best results, but this combination certainly shows promise.